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These tails are subject to a number of put up-translational covalent modifications, together with acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ).

The exception to the rule is the DOT1 household, members of which methylate K79 in the globular area of histone H3 and that are structurally not associated to SET-area proteins four - 6 Current work means that SET-area-containing proteins methylate just a few proteins in addition to histones (see later)